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Our results seem to indicate that the evolution of NKRs is not driven by natural selection, but rather by the natural population dynamics of these cells. Remarkably, as the population of NKRs increases, the number of NKR species decreases, while the number of specificities increases. Figure 3 compares the number of NKRs, the diversity of NKRs, and the number of specificities in three conditions (Fig. 3, top and middle). The diversity of NKRs clearly increases as the population of NKRs increases, while the number of specificities decreases (Fig. 3, bottom). Both diversity and the number of specificities increase only until the number of NKRs reaches its maximum. This suggests that a limit exists to the number of specificities that can coexist in an individual.
The simulations were performed for 200 generations (100 generations per lineage). The constant population size is meant to mimic the constant population sizes observed in natural populations (Bijlsma and Loeschcke 2009). Generation time was set to 3 years, and the simulation stops after 200 generations (Kogan et al. 2001). The number of generations was chosen to match the number of generations reported in Kogan et al.
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One of the drawbacks to this approach was that we needed to recompile every time we made even a small change to the code. This slowed everything else we were doing down and because we couldn't always have someone waiting for the application to finish building. 827ec27edc